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The logical next step is a tantalising one: starve the tumour cells of glucose and you might just bring the big C to its knees.

Not so fast. While glucose is targeted in some cancer treatments, healthy cells also use it as fuel, and so a blanket approach of glucose deprivation can hurt them , too.

Hence the search for a selective means of robbing cancer cells of their precious nutrient. Leveraging the fact that some cancers are more sensitive to glucose denial than others, the team isolated a line of cancer cells that succumbed to glucose starvation within just 10 hours.

Switching focus to their more robust counterparts, they found cells able to resist the enforced famine maintained higher levels of intracellular glucose.

The researchers showed, for the first time, those tiny amounts of glucose had a signalling function which prevented calcium influx and a cascade of molecular changes culminating in cell death.

Both types of cells were then subjected to a two-pronged attack with STF, a compound that inhibits glucose transport into cells, and thapsigargin, which ramps up the level of calcium in cells.

Cells that had that extra glucose in the tank shrugged off the assault, while those that held more meagre reserves went to the wall.

Picking off those relatively depleted tumour cells could, the researchers say, be a winning strategy. Sugar is also fingered as a cancer co-conspirator in separate research published in the Journal of Biological Chemistry.

A team led by Hans Wandall, from the Department of Cellular and Molecular Medicine at the University of Copenhagen, has found that an enzyme responsible for attaching sugar to proteins in colon cells is overactive in gut cancer.

The findings suggest that when the enzyme, called GalNAc-T6, attaches sugars called glycans to bowel cells, it promotes cell adhesion and the formation of tubular structures characteristic of bowel cancer.

Hugh Jackman's sand paintings of the history of sugar is the first of many bite-sized pleasures that make up this rollicking journey of discovery that is guaranteed to disturb your eating habits.

What Gameau reveals about the fructose-laden fare cynically marketed to us at the cost of our health is nothing less than shocking.

The film also stirs the pot about obesity, behavioural problems in children, and even rocks the foundations of consumerism.

He is the canary in the coalmine and we must give thanks for the warning. With great songs and great graphics this film is truly sickening, albeit with an upbeat ending.

Suitable for all the family, That Sugar Film is compulsory viewing for anyone who has children or anything else to live for. Looking for something to watch?

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Crazy Credits. Alternate Versions. Rate This. Damon Gameau embarks on an experiment to document the effects of a high sugar diet on a healthy body.

Director: Damon Gameau. Writer: Damon Gameau. See Showtimes. Added to Watchlist. From metacritic. High School Icons, Then and Now. Use the HTML below.

You must be a registered user to use the IMDb rating plugin. Edit Cast Credited cast: Damon Gameau Self Hugh Jackman Self Rest of cast listed alphabetically: Milla Bakaitis

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One man's journey to discover the bitter truth about sugar. Damon Gameau embarks on a unique experiment to document the effects of a high sugar diet on a healthy body, consuming only foods that are commonly perceived as 'healthy'.

Through this entertaining and informative journey, Damon highlights some of the issues that plague the sugar industry, and where sugar lurks on supermarket shelves.

Written by Madman Entertainment. That Sugar Film is one man's journey into the effect of eating the sugar that is hidden in food marketed as healthy.

There is increasingly awareness that we live in the age of sugar with the population of our planet suddenly consuming massively more sugar.

There are links between this new diet and obesity and mental illness. Warning bells were sounded in by childhood obesity expert Prof Robert H.

Lustig at the University of California, whose youtube lecture went viral. Damon Gameau's playful exploration of this crucially important subject is a big wake-up.

He packages it in a palatable, family-friendly form, the perfect counter-punch to the food industry's current marketing of sugar.

Gameau follows in the footsteps of Morgan Spurlock's gonzo doco, Supersize Me, where Spurlock offered himself as a guinea pig to look at a diet of Maccas.

Here, Gameau puts his body on the line to look behind the health claims of fruit juice, flavoured yoghurt, muesli bars, breakfast cereal and more; a diet only of food marketed as healthy and natural but brimming with heaped spoonfuls of unwanted sugar.

Hugh Jackman's sand paintings of the history of sugar is the first of many bite-sized pleasures that make up this rollicking journey of discovery that is guaranteed to disturb your eating habits.

What Gameau reveals about the fructose-laden fare cynically marketed to us at the cost of our health is nothing less than shocking.

The film also stirs the pot about obesity, behavioural problems in children, and even rocks the foundations of consumerism.

He is the canary in the coalmine and we must give thanks for the warning. With great songs and great graphics this film is truly sickening, albeit with an upbeat ending.

Suitable for all the family, That Sugar Film is compulsory viewing for anyone who has children or anything else to live for.

Looking for something to watch? Choose an adventure below and discover your next favorite movie or TV show. Visit our What to Watch page. Sign In. Keep track of everything you watch; tell your friends.

Full Cast and Crew. Release Dates. Official Sites. For you. Join for free. Compete and win awards. Just a few more seconds before your game starts!

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Here's a few of them. Tell me more Cancel. Picking off those relatively depleted tumour cells could, the researchers say, be a winning strategy. Sugar is also fingered as a cancer co-conspirator in separate research published in the Journal of Biological Chemistry.

A team led by Hans Wandall, from the Department of Cellular and Molecular Medicine at the University of Copenhagen, has found that an enzyme responsible for attaching sugar to proteins in colon cells is overactive in gut cancer.

The findings suggest that when the enzyme, called GalNAc-T6, attaches sugars called glycans to bowel cells, it promotes cell adhesion and the formation of tubular structures characteristic of bowel cancer.

That process, say the researchers, helps refine another target for cancer treatment. Australian experts have stressed that healthy cells are also starved of sugar, unhelpful for a body fighting disease, and that wily cancer cells will just break down fats to make sugar anyway.

Nonetheless, studies have investigated ketogenic diet as an adjuvant treatment in a range of cancers, including ovarian, breast, stomach, brain and lung.

The results, however, are not encouraging.

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